EOS starts Phase I in cancer patients
نویسندگان
چکیده
September 27, 2010, Milan, Italy. EOS S.p.A. (Ethical Oncology Science) announced today the initiation of the first-in-man trial of E-3810, its oral Dual Selective VEGF/FGF protein kinase inhibitor. Patients with advanced solid tumours not amenable to standard therapy will be recruited to this Phase I open-label, dose-escalation trial evaluating the safety profile of E-3810 in order to determine its maximum tolerated dose (MTD) and dose limiting toxicities. The trial will also assess the pharmacokinetics profile and investigate multiple mechanism-related pharmacodynamic markers, including results of blood tests and imaging, to correlate exposure and pharmacological activity in humans.
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